The inflammation found in Crohn’s is considered to be caused by some form of hyper immune/inflammatory response. However, this is a very broad definition and does not really explain what’s seen in the guts of Crohn’s sufferers. For example, the whole gut is not inflamed and the inflammation is not uniformly (evenly) spread out. In fact, if you look carefully at early and late stage Crohn’s, you’ll see a number of small areas of trauma. It might be better to refer to the areas of trauma as wound sites. Here’s the definition of a wound: an injury, especially one in which the skin or another surface is torn, pierced, cut, burned, or otherwise broken.

Also, Tumor Necrosis Factor (TNF) is elevated/increased in CD. And dysregulated TNF is linked to non-healing wounds. See paper below.

Lately, much research has focused on the pro-longed inflammatory phase in non-healing wounds, especially the potential role of the normally regulated tissue necrosis factor-alpha (TNF-a). We describe data suggesting that dysregulated TNF-a is important in the pathogenesis of chronic wounds and discuss evidence that suggests normalizing dysregulated TNF-a might be a potential therapeutic target.
Source: http://www.mendeley.com/research/refractory-ulcers-the-role-of-tumor-necrosis-factoralpha/#page-1

So, is Crohn’s really about multiple and sometimes chronic non-healing wounds? Read about the new way to view Crohn’s disease.