The review below discusses the role of macrophages in the development of post-burn immunosuppression. In particular, the activity of macrophages is “profoundly” increased following a burn, including elevated production of nitric oxide, prostaglandins, TNF-alpha, IL-6, etc.

Major thermal injury induces the activation of an inflammatory cascade that contributes to the development of subsequent immunosuppression, increased susceptibility to sepsis and multiple organ failure. The productive capacity of macrophages for inflammatory mediators, (i.e., nitric oxide, prostaglandins, TNF-alpha, IL-6 etc.), is profoundly increased post-burn, thereby implicating macrophages in the development of the post-burn immunosuppression. This review will focus on recent findings with regards to the role of macrophages in the development of post-burn immunosuppression with particular emphasis on the role of nitric oxide and prostaglandins.
Source: http://www.ncbi.nlm.nih.gov/pubmed/12165794

Unsurprisingly, nitric oxide, prostaglandins, TNF-alpha, IL-6, etc, are also elevated in Crohn’s.

RESULTS: Elevated TNF-alpha, IL-1beta, IL-6, and acute phase proteins were observed in patients with Crohn’s disease. Source: http://www.ncbi.nlm.nih.gov/pubmed/12358255

In Crohn’s disease, elevated inducible nitric oxide synthase activity was found in both normal and inflamed mucosa, with no significant difference between the tissues.
Source: http://www.ncbi.nlm.nih.gov/pubmed/9149061

Increased synthesis of prostaglandins has been observed in inflamed areas of the intestine in active Crohn’s disease.
Source: http://www.ncbi.nlm.nih.gov/pubmed/7865710

Time to wake up and smell the coffee guys